our greatest blessings come to us by way of madness Phaedr. 244a

2012/10/10

Study: Adderall type drugs have no more than small effects on cognition in healthy young adults, although users may perceive the drug as enhancing their cognition.


We don't know the long-term effects of these things. Worth the risk? 

Objective and subjective cognitive enhancing effects of mixed amphetamine salts in healthy people

  • University of Pennsylvania, United States

Highlights

► Mixed amphetamine salts (MAS) have no more than small effect on healthy cognition. ► Despite that, the drug is subjectively viewed as cognitively beneficial. ► Enhancement of a few functions is moderated by baseline ability and COMT genotype.

Abstract

Psychostimulants such as mixed amphetamine salts (MAS, brand name Adderall) are widely used for cognitive enhancement by healthy young people, yet laboratory research on effectiveness has yielded variable results. The present study assessed the effects of MAS in healthy young adults with an adequately powered double-blind cross-over placebo-controlled trial. We examined effects in 13 measures of cognitive ability including episodic memory, working memory, inhibitory control, convergent creativity, intelligence and scholastic achievement, with the goals of determining (1) whether the drug is at least moderately enhancing (Cohen's d >= .5) to some or all cognitive abilities tested, (2) whether its effects on cognition are moderated by baseline ability or COMT genotype, and (3) whether it induces an illusory perception of cognitive enhancement. The results did not reveal enhancement of any cognitive abilities by MAS for participants in general. There was a suggestion of moderation of enhancement by baseline ability and COMT genotype in a minority of tasks, with MAS enhancing lower ability participants on word recall, embedded figures and Raven's Progressive Matrices. Despite the lack of enhancement observed for most measures and most participants, participants nevertheless believed their performance was more enhanced by the active capsule than by placebo. We conclude that MAS has no more than small effects on cognition in healthy young adults, although users may perceive the drug as enhancing their cognition.

This article is part of a Special Issue entitled ‘Cognitive Enhancers’.

http://www.sciencedirect.com/science/article/pii/S0028390812003577

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extra credit: http://www.nytimes.com/2012/10/09/health/attention-disorder-or-not-children-prescribed-pills-to-help-in-school.html?_r=0

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