several things dove-tailed in my mind, and at once it struck me what quality went to form a Man of Achievement, especially in Literature, and which Shakespeare possessed so enormously—I mean Negative Capability, that is, when a man is capable of being in uncertainties, mysteries, doubts, without any irritable reaching after fact and reason ~John Keats
our greatest blessings come to us by way of madness Phaedr. 244a
excessive fructose intake should be considered an environmental toxin with major health implications
*Division of Renal Diseases and Hypertension, University of Colorado, Aurora, Colorado; and
†Department of Nephrology, Ignacio Chávez, Mexico City, Mexico
Correspondence: Dr. Richard J. Johnson, Division of Renal Diseases and Hypertension, Box C281, 12700 East 19th Avenue, Research 2, Room 7015, Aurora, CO 80045. Phone: 303-724-4865; Fax: 303-724-4831; E-mail: firstname.lastname@example.org
Dietary fructose intake is increasing. It is increasing primarily from added sugars, including sucrose and high fructose corn syrup, and correlates epidemiologically with the rising prevalence of metabolic syndrome and hypertension worldwide. The administration of fructose to animals and humans increases BP and the development of metabolic syndrome. These changes occur independently of caloric intake because of the effect of fructose on ATP depletion and uric acid generation. Fructose ingestion may also be a risk factor for kidney disease that includes glomerular hypertension, renal inflammation, and tubulointerstitial injury in animals. We suggest excessive fructose intake should be considered an environmental toxin with major health implications.