excessive fructose intake should be considered an environmental toxin with major health implications

http://jasn.asnjournals.org/content/21/12/2036.short

The Effect of Fructose on Renal Biology and Disease

1. Richard J. Johnson*, 
2. L. Gabriela Sanchez-Lozada^† and
3. Takahiko Nakagawa*

+Author Affiliations

1. ^*Division of Renal Diseases and Hypertension, University of Colorado, Aurora, Colorado; and
2. ^†Department of Nephrology, Ignacio Chávez, Mexico City, Mexico

1. Correspondence:
   Dr. Richard J. Johnson, Division of Renal Diseases and Hypertension, Box C281, 12700 East 19th Avenue, Research 2, Room 7015, Aurora, CO 80045. Phone: 303-724-4865; Fax: 303-724-4831; E-mail: richard.johnson@ucdenver.edu

Abstract

Dietary fructose intake is increasing. It is increasing primarily from added sugars, including sucrose and high fructose corn syrup, and correlates epidemiologically with the rising prevalence of metabolic syndrome and hypertension worldwide. The administration of fructose to animals and humans increases BP and the development of metabolic syndrome. These changes occur independently of caloric intake because of the effect of fructose on ATP depletion and uric acid generation. Fructose ingestion may also be a risk factor for kidney disease that includes glomerular hypertension, renal inflammation, and tubulointerstitial injury in animals. We suggest excessive fructose intake should be considered an environmental toxin with major health implications.

• Copyright © 2010 by the American Society of Nephrology

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