Showing posts with label genome. Show all posts
Showing posts with label genome. Show all posts

2013/10/01

notes: Why Zebras Don't Get Ulcers

Why Zebras Don't Get Ulcers: The Acclaimed Guide to Stress, Stress-Related Diseases, and Coping - Now Revised and Updated

by Robert M. Sapolsky
See this book on Amazon.com


my take: (style influenced by the breathlessly wondrous Sapolsky)

Yes, it's all about the zebras, their lack of affinity for ulcers.

Yes, the book is a truly amazing (amusing, exhausting) chronicle of social- / neuro- biology, what we have learned / surmised / imagined about the nervous system, its basic anatomy / physiology and the way stress affects it (as well as the rest of the body, social group, culture, world) both short and long term (talk about consequences!); the related manipulative / corrective strategies of pharma, physicians, general and psycho-neurologists, clinical psychologists, arm-chair psychologists, alpha-baboons (executives), sociologists, artists, partners, healers, rumor-mongers, and general purveyors of social capital; the sociology, changing views, solutions. Genetics: questions of cause / effect, relationships, heritability, the future re medicine / sociology / profits to be made, heading off disasters of exuberant approach. Principles ("Homeostasis is about tinkering with this valve or that gizmo. Allostasis is about the brain coordinating body-wide changes, often including changes in behavior"). How all this resonates, from/through microscopic to footed-creatures, with a special fixation on humans. All that. Important, wonderful and often course-correcting stuff. (Source, myth, questions of how and why things get mangled.) Politics, geopolitics, (Biopolitics?) .... the idea (quaint, being that of one mid 19 C physician Rudolph Virchow) that "Medicine is social science, and politics nothing but medicine on a large scale... Physicians are the natural attorneys of the poor." The factors / considerations about how poverty might affect all this, and the important (spun, remembered, neglected) corollaries of how attitude, social and personal, might (rich, poor) be surprisingly / cynically relative.

All this. Delivered with humor and humility, questions ever begetting questions. ("Science is not meant to cure us of mystery, but to reinvent and reinvigorate it.")

Sapolsky really is one of my heroes.

But what I really learned from this book is exactly (especially the last paragraph) what I need to learn and apply. To ME. From his conclusion:

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Sometimes, coping with stress consists of blowing down walls. But sometimes it consists of being a blade of grass, buffeted and bent by the wind but still standing when the wind is long gone. Stress is not everywhere. Every twinge of dysfunction in our bodies is not a manifestation of stress-related disease. It is true that the real world is full of bad things that we can finesse away by altering our outlook and psychological makeup, but it is also full of awful things that cannot be eliminated by a change in attitude, no matter how heroically, fervently, complexly, or ritualistically we may wish. Once we are actually sick with the illness, the fantasy of which keeps us anxiously awake at two in the morning, the things that will save us have little to do with the content of this book. Once we have that cardiac arrest, once a tumor has metastasized, once our brain has been badly deprived of oxygen, little about our psychological outlook is likely to help. We have entered the realm where someone else—a highly trained physician—must use the most high-tech of appropriate medical interventions. 
These caveats must be emphasized repeatedly in teaching what cures to seek and what attributions to make when confronted with many diseases. But amid this caution, there remains a whole realm of health and disease that is sensitive to the quality of our minds—our thoughts and emotions and behaviors. And sometimes whether or not we become sick with the diseases that frighten us at two in the morning will reflect this realm of the mind. It is here that we must turn from the physicians and their ability to clean up the mess afterward and recognize our own capacity to prevent some of these problems beforehand in the small steps with which we live our everyday lives. 
Perhaps I’m beginning to sound like your grandmother, advising you to be happy and not to worry so much. This advice may sound platitudinous, trivial, or both. But change the way even a rat perceives its world, and you dramatically alter the likelihood of its getting a disease. These ideas are no mere truisms. They are powerful, potentially liberating forces to be harnessed. As a physiologist who has studied stress for many years, I clearly see that the physiology of the system is often no more decisive than the psychology. We return to the catalogue at the beginning of the first chapter, the things we all find stressful—traffic jams, money worries, overwork, the anxieties of relationships. Few of them are “real” in the sense that that zebra or that lion would understand. In our privileged lives, we are uniquely smart enough to have invented these stressors and uniquely foolish enough to have let them, too often, dominate our lives. Surely we have the potential to be uniquely wise enough to banish their stressful hold. 
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It's the wisdom of Sophocles: Bend, not break.

(and live to fight another day.)

Aha.

Yes -- he's on youtube and Ted.

This is the last lecture -- if you get time, watch it, even if just from 38 minutes on. The whole great wisdom of perspective and tolerance:

http://www.youtube.com/watch?v=-PpDq1WUtAw&feature=player_embedded#!

The original baboon stress doc:

http://www.youtube.com/watch?feature=player_embedded&v=eYG0ZuTv5rs

Ted:

http://www.ted.com/speakers/robert_sapolsky.html


Best, Deborah
Shared Notes & Highlights

2012/09/19

the 9 billion names for god

Wanted to share this. The whole series -- amazing. Been watching it all summer, some parts over and over. This is the last lecture -- if you get time, watch it, even if just from 38 minutes on. The whole great wisdom of perspective and tolerance, things we need to have to go on. Sapolsky. What a teacher. Love him. http://www.youtube.com/watch?v=-PpDq1WUtAw&feature=player_embedded#!

extra credit:
http://downlode.org/Etext/nine_billion_names_of_god.html

http://www.youtube.com/watch?v=NNnIGh9g6fA&feature=related

http://themoonsfavors.blogspot.com/2012/07/stress.html

2012/08/04

alpha baboons

Robert Sapolsky, one of my big heroes (and not an alpha baboon). Some links follow, but apply his work to the New Scientist article dn22071 July 2012 issue 2875 : Inequality: Why egalitarian societies died out

excerpt:

"We cannot assume that because inequality exists, it is somehow beneficial. Equality - or inequality - is a cultural choice..."

"[...] inequality might exacerbate selection on an individual level for high fertility, competition, aggression, social climbing and other selfish traits."

And maybe -- alpha baboons?

Watch:



 more:

http://themoonsfavors.blogspot.com/search?q=sapolsky

http://www.pbs.org/programs/killer-stress/



http://www.ted.com/speakers/robert_sapolsky.html

2012/07/03

stress

Deal with it. Great resource: http://missinghumanmanual.com/?tag=robert-sapolsky



Had interesting conversation last week. Really more of a grilling. E.g., -- What's wrong with making a profit? the stranger kept repeating. I'd mentioned this bit about fracking, from which one can extrapolate what's wrong when it's wrong: that it's not a "free market" or even true "profit" when the Job Creators aren't paying the true cost of production, selling a local resource overseas which they've taken from the public by stealth, rape and permanent pillage of land and water here. In fact, it has the logic system of a cancer. But he seemed more intent on protecting his premise that "human nature" is violence, and "Nature" bound in blood. "Red tooth and claw" he liked to repeat. The past century, all history is violence and war, he says, human nature saved only by the gentling force of "Civilization."

So then -- "civilization" came falling on violent-natured man, fell from sky, was found under rock? Brought by angels and magic djinns? Or could it not also be "human nature"? What's in your frontal cortex? Hm?

Lioness chases wildebeest, kills and drags it back to her cubs. Then all settle down beside the lake, sated. But no, she doesn't take out her rifle and shoot the whole damn herd. And accidents happen. No, we don't live forever; no creatures do. Should we blame a god for this? Blame nature? What has blame to do with it? "All things flow." Minor chords enrich the piece. Torque: Imbalance is simply needed to make the gradients necessary for movement. For life. Even for time. Nothing happens without it.

Life is Mystery.  Are you game? Will you make yourself, body, heart, soul from it?

What I know is that I celebrate all the wars we didn't have. Like peace and civilization, wars don't "happen" to us either. I posit that it was good food, clean air, balance, and love that carried me and you here. An absence of violence. Brought about by? Thank you, ancestors. Thank you for your efforts to cooperate.

And now? Please don't let us be cut off at the knees. The Mad Men of winner-take-all, like the robber-barons of any gilt-age, have silenced our thinking with ---> anything that works, just silence the human brain and all it has learned on its long journey through nature. Which is this: symbiosis is the principle of what endures. All else is like a cancer, a seed-eating flash-in-the-pan that will ultimately burn itself out, taking all it touches with it.

The environment shapes us all at every moment, even down to our genes. In cultures that live behind glass -- windshields, TV, computer screens -- who do we become? How do we communicate, touch, know one another? The anonymity of the more-equal sunders the life-sustaining web of planetary life. To lose true community, to be cut into factions, we lose the harmonic relationships where we (above all, children) experience the wisdom of thoughtful balance, the sacred sphere of learning one another and thus self, understanding that even in our diversity, we are our oneness.

(also published here)

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Once again:

If you put your hands on this oar with me, they will never harm another, and they will come to find they hold everything you want. If you put your hands on this oar with me, they would no longer lift anything to your mouth that might wound your precious land that sacred earth that is your body. If you put your soul against this oar with me, the power that made the universe will enter your sinew from a source not outside your limbs, but from a holy realm that lives in us. Exuberant is existence, time a husk. When the moment cracks open, ecstasy leaps out and devours space; love goes mad with the blessings, like my words give. Why lay yourself on the torturer's rack of the past and the future? The mind that tries to shape tomorrow beyond its capacities will find no rest. Be kind to yourself, dear ­ to our innocent follies. Forget any sounds or touch you knew that did not help you dance... ~ Rumi ~


2012/04/15

Healing Pat Robertson's Demons

Saw this video on Maddow's blog. Touches a nerve, the core of what is so frightening and blinding as we make our way through a changing world. Simply, all that stuff about human behavior Sapolsky has us explore, and a depth psychology that understands that humans live an interstitial existence between the physical body / world and the inner dialogue of dreams, wishes, imagination: the psyche. Both are what we are, the forces and complications of our most measured thinking and our knee-jerk behavior reflexes. Robertson's thinking, lacking all humility as it interprets each moment through his own demonic filter, is truly psychotic:
 

Think. Think metaphorically. All those dismemberment myths from Dionysus to Christ had deity falling into Time and shattering into shards, pieces, the scintilla of soul scattered to make the world, life, etc. These are myths of our own falling out of the unconscious world into the conscious (especially with the creation of language, our tool of thought). "Splitting off from nature," we framed it. Long, long ago it was sensed that we also bring that shattered Oneness back together. The cup of remembrance (Er, Mnemosyne ) from Plato, the rituals of ecstasy, the re-collection of the Mass (where priest and congregation are all part of the process... "do this in memory *with* me") -- all are symbolic rituals that draw their meaning from the process of individuation, "acting the process out" in varying degrees of consciousness. A movement, a process.

All of which gets lost in fundamentalism. In "pinning down" the ineffable, fleshing out the symbolic into "flesh".

When I speak of djinns and angels here, it's in reference to the inner dialogue, projections and transformation of the peace and drama we create from things floating around in us, both known and unknown, and the nets we cast as we draw the world inside us. Not literal, but -- like mythos and religion -- literary, poetic, sometimes deliberately psychologically protective and searching. It's playful, metaphorical, the voice of the psyche. It even hopes to be aligned with what we know about history. But I'm aware of all that. As aware as I can be. (Extra credit: McGilchrist.)

Often it's the Pat Robertsons I'm trying to speak to, because their psychosis and all it shapes is foisted on children. On adults who vote. Presently, it holds a whole nation hostage. I don't know how to make them better. I only know to try, because we live in a world that belongs and depends on the work of all of us. That it's only as whole and well as we are. What beats my heart, beats your heart. Beats everyone's heart. That's the heart I speak from, the only faith I know.

"The devil is a symptom of consciousness," Jung said. What in the hell did he mean by that? Jung, a doctor, Jung also an ancient historian.

Let's take a stab at it.


demonic links to explore:

http://www.brynmawr.edu/classics/redmonds/H11-CSTS212.html

http://haldjas.folklore.ee/folklore/vol9/plotinus.htm

http://ccat.sas.upenn.edu/psco/year25/

Agathodaemon


As a species, we see ourselves as the "eyes and ears of a planet." That phrase comes from Joseph Campbell, and it's a metaphor for simple human consciousness, that thing that scripture, read poetically, which is how it was originally written, claims makes us in (an equally poetic) god's image. It speaks of the psyche of creatures who use language, beings split off from unconscious nature into consciousness. In the lysis of current Western culture, the awareness of this split goes back to a mysticism perhaps expressed best perhaps by Philo -- the deep meaning of the logos. As Jung points out, a literal consciousness distorts that meaning, thinking itself the whole shebang. We thus have that business of a mutable and evolving relationship with the unconscious, seen as the daimon in all his guises -- be it simply as the benign voice of the unconscious, or  Robertson's evil tempter, or the connection back to Self -- to wholeness. These thousand names for deity project our attitude towards the unconscious, an attitude that defines an individual's conscious orientation.


Some notes on concept demon:

2012/04/13

Please watch Sapolsky

So. First arm, now hand impaired. They're trying to tell me something.Think I've found it.

Time to watch, retool. Been immersed in Robert Sapolsky's work -- his Stanford class on Human Behavior Biology is online, whole. If only everyone would watch it. Try the first lecture and let him convince you why.

Stephen -- you need to interview him.

My perspective: lotsa of  changes coming and in the works regarding the way we heal and live. Medicine, especially. With all the emphasis and money shaping the APPLICATION (that was a mistake, caps locked, but let's leave it) of what we're learning about the genome, my mind spins. No end of scenarios for spec fic / fiction, which is my bag. But think: People already paying gobs of money to have a tiny fraction of their genetic material analysed for markers and tendencies. Big business, and how will this affect / effect research, what gets entrenched, what to grasp and let go of (ala what happened with hydrocarbons /oil vs. developing alt.energy), how it's applied?  People, we need to get educated on how to think about this, and not leave it to pharma and the free-market god and its handmaid Fundamentalists.

Not hard to understand that this is not a good time to be filtered by Facebook and web-bots, sorted into bubbles by Murdocian empires, etc.

Please watch Sapolsky.  (Also at http://www.virtualprofessors.com/stanford-bio-250-human-behavioral-biology )

extra credit peruse n extrapolate (and as we said...): http://ghr.nlm.nih.gov/

2012/04/09

Robert Sapolsky How Metaphors Work In Psychology and the Brain

extra credit: relate to Ekphrasis. extra extra credit: how does this concept change / relate to its time

more Sapolsky